005 | Nuances of immunity - Vaccinated and Infection acquired | Steven Templeton

Dr. Steven Templeton is an associate professor at the University of Indiana in Microbiology & Immunology, today we discuss some of the nuances around immunity and immunology such as the difference between vaccine induced and infection acquired immunity, as well as pulling from his knowledge working at the CDC & NIOSH (National Institute for Occupational Safety & Health) - two of the governmental agencies with influence to the USA's national response to disease. We also touch on the effectiveness of some of the non pharmaceutical interventions (NPI's) such as lockdowns & masking as to whether or not they were appropriate responses. 

I would urge you to, if you've interest in immunology, to check out Steve's substack https://stemplet74.substack.com/ - for some incredibly well written - and importantly, well referenced pieces - much like the over arching mantra of The Open Forum podcast - don't take mine or Steve's word for it - have a look at the research! Tune in to find out more!

00:47 Intro
03:00 Advisor to local school board
06:40 Should those with only infection acquired immunity ("natural immunity") be worried for further rounds of COVID?
08:17 Nuances around vaccine induced and infection acquired immunity 
10:40 Antibody levels don't equate to overall immunity
12:10 Antibody Dependent Enhancement - what is that?
14:00 How could we mitigate our risks?
17.30 Does taking medication alter your immune response in any meaningful way compared to vaccination ie - does medication decrease long term immune response.
19:50 difference in immunity required from vaccine or infection 
24:50 gut vs airway vaccine
26:30 mRNA vaccine - omicron/delta/alpha variants
29:40 Do we need boosters every few months, what do the different approaches mean for the data?
31:25 Non Pharma Intervention's (lockdowns) had a minimal effect (0.2%!) was there any place for NPI's? 
40:30 Masking was it really useful?
46:20 South Korea study - children were equal to adults in transmission?  
57:35 immunosenescence is why older folks and not younger kids??
1:00:00 what does the average age of death from covid tell us?
1:02:50 how does cross infection immunity help?
1:03:45 Advice to returning back to normal

Steve's Substack 
https://stemplet74.substack.com/ 

Infection vs Vaccination acquired immunity (lots of articles referenced here)
https://stemplet74.substack.com/p/infection-vs-vaccination-acquired?s=r

Johns Hopkins study 
https://sites.krieger.jhu.edu/iae/files/2022/01/A-Literature-Review-and-Meta-Analysis-of-the-Effects-of-Lockdowns-on-COVID-19-Mortality.pdf 

Jeffrey Tucker Browstone Institute article 
https://brownstone.org/articles/did-china-do-it-right/

CDC mask study Feb 2021 release
https://www.cdc.gov/mmwr/volumes/70/wr/mm7007e1.htm?s_cid=mm7007e1_w

South Korea study
https://jamanetwork.com/journals/jamapediatrics/fullarticle/2770150?guestAccessKey=76a96512-c278-4968-a343-678474c1c1be&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=082820